Corona Virus: It's a Marathon, Not a Sprint

[malchior]

Yup. Read about it here:

On the CDC site where data on available hospital beds and ICU was previously stored, a note now reads, “Data displayed on this page was submitted directly to CDC’s National Healthcare Safety Network (NHSN) and does not include data submitted to other entities contracted by or within the federal government.”

“We don’t have this critical indicator anymore,” Panchadsaram said. “The intent of just switching the data streams towards HHS, that’s fine. But you got to keep the data that you’re sharing publicly still available and up to date.”

Panchadsaram said he and his team, which includes researchers from the Duke-Margolis Center for Health Policy and from Resolve to Save Lives, a public health initiative led by former CDC director Dr. Tom Frieden, have been tracking the data since April.

The whole thing astounds me. This flies in the face of the bare basic minimum standard of care - so to speak - that you need to achieve when you are cutting over a critical information resource *in the middle of a damn crisis*. The new platform needs to exist and you need to transition it to such a way that you don't interrupt the damn service. We don't know if the platform exists, works...we don't know anything.

[Kraken]

What is the timeline for vaccine development, anyway?

Some are in testing now. At what point does Pharma declare a series of tests successful and announce production? And how long is it from then until the average person can expect to get the shot?

In other words, what's the lag time between science having a vaccine and our bloodstreams having it?

Depend on how safe you want it to be. Usually it's a year plus for new vaccines. There is extreme political and economic pressure to get it out ASAP, trials and testing be damned.

If the Moderna vaccine is the first to market and it's before the end of this year, I will take my sweet time to get vaccinated. I don't like beta testing released games, I sure as hell won't beta test released drugs.

Here's a good look at the Moderna vaccine's potential path forward.

The difference between an early-stage trial involving 45 volunteers and a late-stage trial involving 30,000 is, as Mark Twain once characterized another comparison, “the difference between the lightning-bug and the lightning.”

Most experimental drugs and vaccines fail to make it all the way through clinical trials, and there are many unanswered questions about Moderna’s Phase 3 trial, according to experts who weighed in the day after the New England Journal of Medicine reported the vaccine had stimulated a robust immune response in the small Phase 1 trial.

Those questions include whether it will produce similar results in a much larger group of volunteers, how long the immune response lasts, and whether side effects observed in many subjects will remain generally mild. The company has said that some data on how the massive trial is going could be available by the end of the year.
...
Carr wrote to investors Wednesday that Moderna previously said that “at least interim data may be feasible” by the end of this year. And if the vaccine is approved by the Food and Drug Administration, the company hopes to deploy it some time next year.

Phase 3 trials rarely go ideally, so that's their best-case scenario.

[Isgrimnur]

[Defiant]

Russian cyber actors are targeting organizations involved in coronavirus vaccine development, according to a new warning by US, UK and Canadian security officials on Thursday that details activity by a Russian hacking group called APT29, which also goes by the name "the Dukes" or "Cozy Bear."

An advisory published by the UK National Cyber Security Centre (NCSC) details activity by the Russian hacking group and explicitly calls out efforts to target US, UK and Canadian vaccine research and development organizations.
"APT29's campaign of malicious activity is ongoing, predominantly against government, diplomatic, think tank, healthcare and energy targets to steal valuable intellectual property," a press release on the advisory said.

UK, US and Canada allege Russian cyberattacks on Covid-19 research centers

[El Guapo]

JFC. Just when you thought that the GOP couldn't get any more insane:

https://twitter.com/GovAndyBeshear/stat ... 1762452483

On the heels of Kemp banning localities in GA from requiring masks. It's just completely insane, both in terms of people dying and in terms of any Republicans remaining in office after the fall.

[Unagi]

who's this AG?

This is insane, seriously - what is behind these thoughts... They honestly don't think this virus is a threat?

[El Guapo]

who's this AG?

The Kentucky state AG (not Barr). Don't know much about him, but I'm inferring from this that he's some trumpist lunatic.

[Paingod]

JFC. Just when you thought that the GOP couldn't get any more insane:

https://twitter.com/GovAndyBeshear/stat ... 1762452483

On the heels of Kemp banning localities in GA from requiring masks. It's just completely insane, both in terms of people dying and in terms of any Republicans remaining in office after the fall.

Is this Hitler screaming from the bunker level crazy yet? It's obvious that COVID-19 is his enemy, but who's Hitler here?

[Remus West]

?

[Unagi]

who's this AG?

The Kentucky state AG (not Barr). Don't know much about him, but I'm inferring from this that he's some trumpist lunatic.

Yeah, I just assumed the state AG worked at the behest of the Gov. I mean, I don't mean like the way Barr does for Trump, but I mean - can't the governor put someone in place that's not a lunatic?

[Isgrimnur]

https://en.wikipedia.org/wiki/Daniel_Ca ... olitician)

[Unagi]

?

If you look at the first letter of each line, it reads: "I AM THE SEER"

[El Guapo]

who's this AG?

The Kentucky state AG (not Barr). Don't know much about him, but I'm inferring from this that he's some trumpist lunatic.

Yeah, I just assumed the state AG worked at the behest of the Gov. I mean, I don't mean like the way Barr does for Trump, but I mean - can't the governor put someone in place that's not a lunatic?

Many (I think most) state AGs are independently elected. Definitely works that way in Massachusetts.

[Unagi]

https://en.wikipedia.org/wiki/Daniel_Ca ... olitician)

Cameron is the first Republican elected to the office since 1944 and is the first African-American Attorney General of Kentucky.


ok, so he is elected.

[Isgrimnur]

Nobel Laureates

?

You can be an LN in Economics, Literature, Peace, etc. Doesn't equate to those for Physiology or Medicine.

[Paingod]

If you look at the first letter of each line, it reads: "I AM THE SEER"

I need to get my eyes checked. I see MCOLWBCPEMSMAJA

[Unagi]

Nobel Laureates

?

You can be an LN in Economics, Literature, Peace, etc. Doesn't equate to those for Physiology or Medicine.

back peddling on the Seer claim?

 Issy 
 

[Remus West]

Damn you, Unagi. I looked for the pattern.

[Unagi]

If you look at the first letter of each line, it reads: "I AM THE SEER"

I need to get my eyes checked. I see MCOLWBCPEMSMAJA

It's Yiddish

[Isgrimnur]

For instance, Michael Rosbash is one of three winners for PorM "for their discoveries of molecular mechanisms controlling the circadian rhythm."

Seems like the perfect guy to talk to about viral vaccines, no?

[Isgrimnur]

Jack W. Szostak (2009) "for the discovery of how chromosomes are protected by telomeres and the enzyme telomerase"

You know who I don't see on the list?

Bruce A. Beutler, Jules A. Hoffmann (2011) "for their discoveries concerning the activation of innate immunity"

The major functions of the vertebrate innate immune system include:
* Recruiting immune cells to sites of infection through the production of chemical factors, including specialized chemical mediators called cytokines

[stessier]

For instance, Michael Rosbash is one of three winners for PorM "for their discoveries of molecular mechanisms controlling the circadian rhythm."

Seems like the perfect guy to talk to about viral vaccines, no?

The reason you posted the list is on the last page - it's possible people aren't making the connection.

[Scraper]

https://www.washingtonpost.com/outlook/ ... rc404=true I didnt see this posted anywhere else, but damn that is one brutal first hand account of Trump's complete failure to lead. From a GOP governor no less.

[Isgrimnur]

The reason you posted the list is on the last page - it's possible people aren't making the connection.

Pesky details.

A number of important people think we should be doing challenge trials.

Over 100 prominent scientists, including 15 Nobel laureates, are calling for healthy volunteers to be exposed to the coronavirus to see whether vaccines against Covid-19 actually work.

[malchior]

https://www.washingtonpost.com/outlook/ ... rc404=true I didnt see this posted anywhere else, but damn that is one brutal first hand account of Trump's complete failure to lead. From a GOP governor no less.

What a great piece. And very brave of him politically.

Edit: as expected here come the comments - how dare anyone criticize the dear leader.

Gov. Hogan, this message is for you.

If you still think you can call yourself a Republican, you'd be wrong.

It's not a party anyone with your values should be associated with.

Go Independent to keep your own values that are not in keeping with the Republicans.

[El Guapo]

https://www.washingtonpost.com/outlook/ ... rc404=true I didnt see this posted anywhere else, but damn that is one brutal first hand account of Trump's complete failure to lead. From a GOP governor no less.

What a great piece. And very brave of him politically.

Edit: as expected here come the comments - how dare anyone criticize the dear leader.

Gov. Hogan, this message is for you.

If you still think you can call yourself a Republican, you'd be wrong.

It's not a party anyone with your values should be associated with.

Go Independent to keep your own values that are not in keeping with the Republicans.

Though that could be written from the left-wing or the right-wing.

[Smoove_B]

Hello facepalm, my old friend...

https://twitter.com/carlzimmer/status/1 ... 0237716481

Scene from a meeting in Utah to discuss requiring masks and social distancing at schools this fall. Contact tracers, start your engines. https://sltrib.com/news/education/2020/ ... ting-utah/ [Photo by Rick Egan | The Salt Lake Tribune]

[Isgrimnur]

That poor guy in the middle...

[The Meal]

Hello facepalm, my old friend...

https://twitter.com/carlzimmer/status/1 ... 0237716481

Scene from a meeting in Utah to discuss requiring masks and social distancing at schools this fall. Contact tracers, start your engines. https://sltrib.com/news/education/2020/ ... ting-utah/ [Photo by Rick Egan | The Salt Lake Tribune]

[Paingod]

That poor guy in the middle...

At least he won't get anyone sick. Can't say though how well he fared with what they were spreading.

[malchior]

Nobel Laureates

?

You can be an LN in Economics, Literature, Peace, etc. Doesn't equate to those for Physiology or Medicine.

I was wondering this too. How many have backgrounds in medical ethics? Would that actually speed anything up?

[LawBeefaroni]

I counted two other mask wearers (not counting the chin-maskers). So like a 3-4% rate?

[El Guapo]

I'm just really happy to be from Massachusetts right now. Not that there aren't plenty of idiots around here....but hey, at least we seem to be in the top tier for this country on this kind of shit.

[$iljanus]

Hello facepalm, my old friend...

https://twitter.com/carlzimmer/status/1 ... 0237716481

Scene from a meeting in Utah to discuss requiring masks and social distancing at schools this fall. Contact tracers, start your engines. https://sltrib.com/news/education/2020/ ... ting-utah/ [Photo by Rick Egan | The Salt Lake Tribune]

SUCK IT SCIENCE NERDS!

BREATHE FREE OR (and) DIE!

[Zaxxon]

I'm just really happy to be from Massachusetts right now. Not that there aren't plenty of idiots around here....but hey, at least we seem to be in the top tier for this country on this kind of shit.

[$iljanus]

I'm just really happy to be from Massachusetts right now. Not that there aren't plenty of idiots around here....but hey, at least we seem to be in the top tier for this country on this kind of shit.

Especially on a really beautiful day like today when it's not 95 degrees and high humidity! Suck it maskless hordes!

[Zaxxon]

Governor Polis finally found some stones...

Colorado on statewide mask order starting Friday.

[Smoove_B]

You can't make this stuff up - Florida emergency management center shut down:

A surging wave of coronavirus infections that developed in Florida this past week has landed at the state’s Emergency Operations Center, which is managing the pandemic response around the clock.

The Division of Emergency Management announced via Twitter Thursday morning that 12 workers at the EOC have tested positive for the virus that triggers COVID-19, a potentially fatal respiratory disease. Four of those results were returned this week.

A spokesman said the EOC facility at Southwood in Tallahassee is undergoing a deep cleaning and is closed until Monday. Workers will be working virtually in the meanwhile.

[Unagi]

Governor Polis finally found some stones...

Colorado on statewide mask order starting Friday.

Oysters

[Smoove_B]

That is good news about CO. Hopefully it's something the people widely support. I'll fully admit I haven't been following everything that closely.