I think that here on OO we have a nice representation of more adult, intelligent, qualitity-minded, good-looking gamers, and, we even have a few game designers look in on us, once in while (No, not you Derek, please...)
I have a dream myself...
Basically, you could call it Rome:TW in space. Only, I had the idea before RTW did

Its a turn-based strategy game, set in deep space. The focus is on research, empire management, and of course, the occasional space war, with galaxy spanning consequences.
Space battles would be possbile to fight out in 3D battles, fleet-wise, with ability to pause, and give new orders.
Graphics must of course, be good, and musical score should fit the deep-space theme.
In addition to this, there should be governors and leaders, giving various boosts to various areas.
The galaxy should be alive, teeming with alien races, special events, both local and galaxy spanning.
Some of the events, are diplomatic in nature, relating to your own empire (Not unlike Nationstates), others are dealing with new forces in the universe, disasters, rebels and so forth.
Diplomacy should be reminiscent of Master of Orion 2's diplomacy, only with more options, and should actually be a viable way to winning to game, especially with the use of espionage/sabotage as well.
hmm, looking at this, its basically what Moo3 shoild have been...sigh...
So, let me hear, what would YOUR favorite game be?